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HAM621S-HAEMATOLOGY 2B- JAN 2020 |
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NAMIBIA UNIVERSITY
OF SCIENCE AND TECHNOLOGY
FACULTY OF HEALTH AND APPLIED SCIENCES
DEPARTMENT OF HEALTH SCIENCES
QUALIFICATION: BACHELOR OF MEDICAL LABORATORY SCIENCES
QUALIFICATION CODE: O8BMLS
LEVEL: 6
COURSE CODE: HAM621S
COURSE NAME: HAEMATOLOGY 2B
SESSION: JANUARY 2020
DURATION: 3 HOURS
PAPER: THEORY
MARKS: 100
SUPPLEMENTARY / SECOND OPPORTUNITY EXAMINATION PAPER
EXAMINER(S)
MAURICE NYAMBUYA
MODERATOR:
ELZABE VAN DER COLF
INSTRUCTIONS
1. Answer ALL the questions.
2. Write clearly and neatly.
3. Number the answers clearly.
PERMISSIBLE MATERIALS
1. Pen
2. Calculator
THIS QUESTION PAPER CONSISTS OF 4 PAGES (including this front page)
Page 1 of4
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SECTION A [50]
QUESTION 1
[10]
Write short notes on the following terms;
1.1 Leukemoid reaction.
(2)
1.2 Leukoerythroblastosis.
(2)
1.3 Gaucher's disease.
(2)
1.4
Neimann Pick disease.
(2)
1.5
May-Hegglin anomaly.
(2)
QUESTION 2
[15]
2.1 Tabulate the differences between T and B-cell lymphocytes.
2.2. The heterophile antibody test (monospot) is used in the diagnosis of
mononucleosis. Describe the test and state its principle.
(7)
QUESTION 3
[25]
3.1 Name and describe the three phases of carcinogenesis.
3.2 List and explain 5 characteristics that a disease must meet to be classified as
malignant.
(10)
3.3
State the Coulter principle and describe its use in haematology automation.
(9)
Page 2 of 4
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SECTION B [50]
QUESTION 4
[25]
A 58-year-old man had been complaining of progressive tiredness for many months. Recently
he had noticed that he was bruising easily and was experiencing night sweats. A physical
examination by the doctor revealed that he had hypertension, a slight fever and an enlarged
spleen. A full blood count, differential count and a LAP score test were requested.
Full blood count
Differential count
White Cell Count | 20.6 | X10°/I
Neutrophils
38%
Red Cell Count
3.6
X10?2/I
Band cells
13%
Haemoglobin
10.8 | g/dl
Metamyelocytes
9%
Platelets
600 | X10%/I
Myelocytes
10%9g
Promyelocytes
2%
Peripheral blood smear
Pe
Eosinophils
1%
Basophils
1%
Lymphocytes
21%
Monocytes
3%
Blasts
2%
Nucleated red blood cells | 15%
4.1 Correct the white cell count (show all calculations)
(4)
4.2 The total cell numbers were as follows; A=90 ; B=5; C=3;D=2 and E=0. Calculate the
LAP score (show all calculations).
(7)
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4.3 Based on your LAP score above, what is most likely to be the diagnosis for this
patient?
(2)
4.4 Name other condition in which the LAP score is useful and the expected score
value.
(2)
4.5 What other further test will do to confirm the diagnosis in 4.3.
(10)
QUESTION 5
[25]
5.1 List 6 categories in which the World Health Organisation (WHO) classified
myelodysplastic syndrome into.
(6)
5.2 Of the MDS classification you have listed above, which category is most likely to
progress into acute myeloid leukaemia. Motivate your answer.
(4)
5.3 Discuss the pathogenesis, clinical findings as well as laboratory results of
chronic myelomonocytic leukaemia (CMML).
(12)
5.4 What disorder is CMML classified as according to the WHO? Explain the rationale
behind this classification.
(3)
End of Examination
Total Marks: [100]
Good Luck!
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