 |
ICP420S- INTEGRATED CLINICAL PATHOPHYSIOLOGY - JAN 2020 pdf |
|
|
1 Page 1 |
▲back to top |
NAMIBIA UNIVERSITY
OF SCIENCE AND TECHNOLOGY
FACULTY OF HEALTH AND APPLIED SCIENCES
DEPARTMENT OF HEALTH SCIENCES
QUALIFICATION: BACHELOR OF BIOMEDICAL SCIENCES
QUALIFICATION CODE: 50BBMS
LEVEL: 8
COURSE CODE: ICP420S
COURSE NAME: INTEGRATED CLINICAL
PATHOPHYSIOLOGY
SESSION: JANUARY 2020
DURATION: 3 HOURS
PAPER: THEORY
MARKS: 160
SUPPLEMENTARY / SECOND OPPORTUNITY EXAMINATION QUESTION PAPER
EXAMINER(S)
DR MUNYARADZI MUKES!
MODERATOR:
PROF GLENDA DAVISON
INSTRUCTIONS
1. Answer ALL the questions.
2. Write clearly and neatly.
3. Number the answers clearly.
PERMISSIBLE MATERIALS
1. NON PROGRAMMABLE CALCULATOR
THIS QUESTION PAPER CONSISTS OF SIX PAGES (including this front page)
Page 1 of 6
|
|
2 Page 2 |
▲back to top |
SECTION A [30]
QUESTION 1
[10]
1.1
Propose FOUR routine chemistry tests that can be performed in a small Clinical Pathology
Laboratory on a patient with Acute Pancreatitis
(4)
1.2
Write short notes on CRP ( C— Reactive Protein)
(4)
1.3
It is recommended that a patient who is to undergo an occult blood test, should follow a
special diet for at least 2 days. Name 2 food-types that this patient should
avoid.
(2)
QUESTION 2
[10]
2.0
Glucose in the extracellular fluid is strictly regulated by complex and interrelated
endocrine and metabolic processes. Briefly describe the FIVE most important hormones
that regulate blood glucose concentration.
(10)
QUESTION 3
[10]
3.0
Discuss the laboratory findings in Diabetic Ketoacidosis
SECTION B [30]
QUESTION 4
[10]
4.0
The blood from a patient with full-blown AIDS is received. Describe the peripheral blood
smear findings that would be constant with the clinical status.
QUESTION 5
[12]
5.1
Describe the characteristic morphological findings of the following:-
5.1.1
Pelger Huet Anomaly
5.1.2. May-Hegglin Anomaly
5.1.3. Chediak-Higashi Anomaly
(4)
Page 2 of 6
|
|
3 Page 3 |
▲back to top |
5.2
What are the functions of von Willebrand factor?
(3)
5.3 Name any five red cell abnormalities seen in the peripheral blood following
splenectomy.
(5)
QUESTION 6
[8]
6.0 Two technologists, Anna and Petrus are in the haematology laboratory in
Otjiwarongo. They received a specimen of a 19-year male patient who complained
of a sore throat, ear-aches, headaches and occasional fever. The clinician ordered
a full blood count and ESR. The blood picture showed prominent reactive
lymphocytes. The FBC results are as follows:
Patient results
WCC
HB
MCV
PLTs
Neutrophils
Lymphocytes
Monocytes
Eosinophils
16.7 x 109/L
15.9 g/dL
92.5 fl
136 x 10°/L
25%
68%
6%
1%
Anna is convinced that the patient has AML M3 (Acute promyelocytic leukaemia)
but however Petrus disagrees. They get into a heated argument over the diagnosis
of which the pathologist overhears and comes in to calm the situation. He hears
both sides of the stories and agrees with Petrus that this is not a case of AML M3.
6.1 Build a case supporting Petrus and the pathologist as to why this diagnosis is not
AML M3.
(8)
Page 3 of 6
|
|
4 Page 4 |
▲back to top |
SECTION C [30]
QUESTION 7
[14]
7.1
Identify TWO common parasites classified as trematodes.
(2)
72
Describe the laboratory procedure used to identify the presence of the ova of the
trematodes given in (a).
(8)
ha
Draw a labelled sketch of one of the ova of the trematode named in (a).
(2)
7.4
Briefly explain how the sample is collected for the identification of the ova of Enterobius
vermicularis and explain why this method is necessary.
(2)
QUESTION 8
[8]
8.0
You have received a faecal specimen from a child with suspected dysentery. Give the
laboratory diagnosis and expected results from:
8.1 Microscopy
(2)
8.2
Culture
(6)
QUESTION 9
[3]
9.0
Use a table to differentiate between Neisseria gonorrhoeae and Neisseria meningitidis by
their acid production from Glucose, Maltose, Sucrose and Lactose.
9.1
Glucose
9.2
Maltose
9.3
Sucrose
9.4
Lactose
N. gonorrhoeae
N. meningitides
Page 4 of 6
|
|
5 Page 5 |
▲back to top |
SECTION D [70]
QUESTION 10
[20]
10.0 Discuss the relevant laboratory findings in Alcoholic Liver Cirrhosis. Give abnormal
parameters, or groups of tests, under the following headings:
10.1 Definition of the above condition.
(3)
10.2 Chemical Pathological laboratory findings.
(11)
10.3. Haematological laboratory findings.
(6)
QUESTION 11
[20]
11.0 You have received a cerebrospinal fluid (CSF) specimen from a 4 year old child who has
been admitted to hospital with suspected meningitis. The CSF appears turbid and the cell
count reveals the following: Polymorphonuclear cells: 2000; lymphocytes: nil; erythrocytes:
nil. The Gram stain revealed Gram positive diplococci.
11.1. What is the most likely organism causing meningitis in this patient?
(1)
11.2 Indicate the media you would inoculate and describe the incubatory conditions you
would use in order to be able to successfully culture this organism?
(3)
11.3. After 24 hours incubation, you obtain growth of the organism. Describe the growth
characteristic features you would look for to identify this organism.
(2)
11.4 Identify one important test that you would set up to confirm the identity of the organism
above.
(1)
11.5 Briefly describe how you would set up and interpret the test mentioned in (d) and
the expected result.
(5)
11.6 With regards to antimicrobial susceptibility testing of this organism: Which antibiotic
disc is recommended by the clinical and laboratory standards institute (CLS!) to
determine penicillin sensitivity?
(1)
11.7. Propose the tests to be performed in clinical chemistry and expected results.
(4)
11.8 Predict the notable white cell characteristics on a peripheral smear of this patient.
(3)
Page 5 of 6
|
|
6 Page 6 |
▲back to top |
QUESTION 12
[10]
12.0 Briefly describe the significance of urinary protein analysis in the diagnosis of disease.
QUESTION 13
[10]
13.0 Using Ebola as an example, briefly describe the pathogenesis of viral haemorrhagic diseases.
Indicate the laboratory tests carried out and expected results.
QUESTION 14
[10]
14.0 Using relevant examples discuss the causes of female infertility.
END OF EXAMINATION
TOTAL 160 MARKS
Page 6 of 6