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CLC711S - CLINICAL CHEMISTRY 3 - 2ND OPP - JULY 2022 |
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nAmlBIA untVERSITY
OF SCIEnCE Ano
FACULTYOF HEALTH,APPLIEDSCIENCESAND NATURALSCIENCES
DEPARTMENTOF HEALTHSCIENCES
QUALIFICATION:BACHELOR OF MEDICAL LABORATORY SCIENCES
QUALIFICATIONCODE: 08BMLS
LEVEL: 7
COURSECODE: CLC711S
COURSENAME: CLINICAL CHEMISTRY 3
SESSION:
JULY2022
DURATION: 3 HOURS
PAPER:
MARKS:
THEORY
120
SECONDOPPORTUNITY/SUPPLEMENTARYEXAMINATION QUESTION PAPER
EXAMINER(S) DR MUNYARADZI MUKESI
MODERATOR: PROF GREANIOUS A. MAVONDO
INSTRUCTIONS
1. Answer ALL the questions.
2. Write clearly and neatly.
3. Number the answers clearly.
THIS QUESTION PAPERCONSISTSOF THREEPAGES(Including this front page)
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SECTION A [60 marks]
QUESTION 1
(20 marks]
Fluid accumulation between serous membranes can be a result of either transudates or
exudates.
1.1 Briefly explain the immunological basis of exudation.
(10 marks)
1.2 Analyse the protein content of exudates, indicating the different protein components and
explain their existence.
(10 marks)
QUESTION 2
{20 marks]
A 77-year-old patient presented with the following results during a follow up after 7 days of
taking Carbamazepine.
Carbamazepine:
20 mcg/ml (4-12)
Albumin:
12 g/L (35-55)
Total protein:
56 g/L (65-85)
Alanine Transaminase (ALT): 1112 U/L (5-45)
Urea:
23.6 mmol/L (2.3-8.5)
Creatinine:
634 µmol/L 60-120)
2.1 Briefly explain the importance of therapeutic drug monitoring in this patient? Motivate
your answer.
(10 marks)
2.2 Discussthe potential causes of the low albumin in this patient. What other tests would
you recommend to establish the cause of the low albumin?
(10 marks)
QUESTION 3
(20 marks]
A 23-year-old female has been brought to the laboratory by the police for blood alcohol
measurement in a suspected case of drunken driving which resulted in the death of four
people. Briefly outline how this sample for blood alcohol analysis should be handled,
focussing on the pre-analytic phase.
SECTION B [60 marks]
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QUESTION 4
[20 marks]
Describe the physiological control of the exocrine secretion of the pancreas. Demonstrate
how this knowledge is applied in the investigation of pancreatic disease.
QUESTION 5
[20 marks]
Give a critical account of the hormonal assessment of infertility in an adult female patient.
QUESTION 6
[20 marks]
Outline the main causes of false negative results during screening for drugs of abuse in
patients.
TOTAL 120 MARKS
END OF EXAMINATION
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