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CMB521S - CELL AND MOLECULAR BIOLGY - 1ST OPP - NOVEMBER 2024 |
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n Am I BI A u n IVER s I TY
OF SCI En CE
TECH n OLOGY
Faculty of Health, Natural
Resourcesand Applied
Sciences
School of Health Sciences
Department of Clinical
Health Sciences
13 Jackson Kaujeua Street
Private Bag 13388
Windhoek
NAMIBIA
T: +264 61 207 2970
F: +264 61 207 9970
E: dchs@nust.na
W: www.nust.na
QUALIFICATION : BACHELORof MEDICALLABORATORYSCIENCES
QUALIFICATION CODE: 0SBMLS
COURSE:CELLAND MOLECULARBIOLOGY
DATE: NOVEMBER 2024
DURATION: 3 HOURS
LEVEL:5
COURSECODE: CMB521S
SESSION: 1
MARKS: 100
FIRSTOPPORTUNITY:QUESTION PAPER
EXAMINER:
MODERATOR:
Ms Belinda Roselin Tsauses
Ms Vanessa Tjijenda
INSTRUCTIONS:
1. Answer all questions in the answer book.
2. Please write neatly and legibly.
3. Do not use the left side margin of the exam paper. This must be allowed for the
examiner.
4. No books, notes and other additional aids are allowed.
5. Mark all answers clearly with their respective question numbers.
PERMISSIBLEMATERIALS:
1. None.
ATTACHEMENTS
1. None.
This question paper consists of 6 pages including this front page.
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1SECTIONA: MULTIPLE CHOICEAND TRUE/ FAL'.SE
QUESTION 1: MULTIPLECHOICEQUESTIONS
[20 MARKS]
[10 MARKS]
Evaluate the statements in each numbered section and select the most appropriate
answer or phrase from the given possibilities. Fill in the appropriate letter next to the
number of the correct statement/phrase in your ANSWERBOOK.
[10]
1.1 The following type of signaling in cell communication represents:
{1)
Signaling
cell
•
•
Target'
cell
a) Endocrine signaling.
b) Paracrine signaling.
c) Direct signaling.
d) Autocrine signaling.
1.2 The diagram below explains that cell communication is taking place by:
(1)
Signaling
cell
Target
cell
a) Only affecting the cells in close proximity.
b) A cell signaling a nearby cell.
c) A cell signaling itself.
d) A cell targeting a neighbouring cell through gap junctions.
Cell and Molecular Biology {CMB521S)
2024
151Opportunity November
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1.3 The following diagram specifically depicts the process of________
cellular transport.
in
(1)
a) Exocytosis.
b) Vesicular transport.
c) Endocytosis.
d) Pinocytosis.
1.4 Receptor-mediated endocytosis is a specialized type of ______
_
(1)
a) Endocytosis.
b) Exocytosis.
c) Pinocytosis.
d) Phagocytosis.
1.5 The complete set of relationships among amino acids and codons is said to be a
(1)
a) Swap.
b) Wobble.
c) Histone.
d) Genetic code.
1.6 The first step of vesicular formation is:
(1)
a) Vesicular budding.
b) Vesicular fusion.
c) Vesicular targeting.
d) Cargo selection.
Cell and Molecular Biology (CMB521S)
2024
151 Opportunity November
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1.7 One of the three (3} pathways of vesicular transport that is responsible for
recycling cellular molecules is known as the:
(1}
a} Secretory pathway.
b) Endocytic pathway.
c} Retrieval pathway.
d) Vesicular pathway.
1.8 The main cell organelles involved in vesicular transport are:
(1)
a} Golgi complex, ribosomes and the mitochondria.
b} Golgi complex, lysosomes and the endoplasmic reticulum.
c) Nucleus, ribosomes and the golgi complex.
d) None of the above.
1.9 In terms of the genetic code, the stop codons are:
(1)
a) UAA, UAG and UGA.
b) UAA, AUG and UGA.
c) UAG, TUG and TAG.
d) UGA, TUG and TAG.
1.10 The first step in the DNA replication process is known as:
(1}
a) Primer binding.
b} Termination.
c) Elongation.
d) Replication fork formation.
Cell and Molecular Biology (CMB521S)
2024
1'1 Opportunity November
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QUESTION 2: TRUE/FALSE QUESTIONS
[10 MARKS]
Evaluate the statements and select whether the statement is true or false. Write the
word 'True' or 'False' next to the corresponding number in your ANSWERBOOK.
[10]
2.1 Resistance to apoptosis is a key characteristic of malignant cells.
{1)
2.2 Cell growth refers to an increase in the total mass of a cell, excluding cytoplasmic,
nuclear and organelle volume.
{1)
2.3 Proliferation refers to the growth and reproduction of cells.
{1)
2.4 Dysfunction of cell adhesion in metastasis and loss of cell-cell adhesion in tumour cells
causesthem to escapetheir site of origin and spread through the circulatory system. (1)
2.5 Cell surface receptors are hydrophobic signalling molecules that typically works
by binding to the extracellular portion of a receptor protein.
(1)
2.6 In cell communication, receptors are protein molecules in the target cell or on its
surface that binds to ligands.
{1)
2.7 The process of DNA duplication is called DNA replication.
(1)
2.8 During the DNA replication process, DNA polymerase joins DNA fragments together
by forming phosphodiester bonds between nucleotides.
{1)
2.9 Before new complementary DNA is formed, there must be a starting point
{primers).
(1)
2.10 Proofreading is important in preventing mutations from occurring in
newly-synthesized DNA.
(1)
SECTION B: SHORT ANSWER QUESrlONS
Pleaseanswer ALL of the questions in this section.
[38 MARKS]
QUESTION 3:
[14 MARKS]
3.1 Name any five (5) important inorganic ions that are transported in
and out of the cell. Indicate the correct charges. {No marks will be awarded to
answers with incorrect charges.)
Cell and Molecular Biology (CMB5215)
2024
(5)
151 Opportunity November
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3.2 From your answers in question 3.1, extract examples of two (2) ions that are
actively transported in and out of the cell using ATP. Indicate which ion is
abundant inside the cell and outside the cell.
(4)
3.3 In your own words, briefly explain the importance of membrane potential in cells
and how it is established.
(6)
QUESTION 4:
[24 MARKS]
4.1 Sketch a neatly labelled diagram showing the two (2) major phases of the cell
cycle. The diagram should clearly indicate the four (4) steps of the two (2) phases
and a brief description of each step. Indicate any sub-divisions of the steps where
applicable.
(12)
4.2 Describe four (4) characteristics relating to the molecular structure of DNA.
(8)
4.3 Nucleotides are molecules that are the basic building blocks of the nucleic acids in
DNA and RNA. Give the full names of the four (4) nucleotides in RNA.
(4)
SECTION C: LONG ANSWER QUESTIONS
[42 MARKS]
Pleaseanswer ALL of the questions in this section. Give your answers in point form.
QUESTION 5:
[18 MARKS]
Detail the steps involved in the transcription processof DNA in the correct order and
draw a labelled diagram to demonstrate your understanding of what is achieved at the
end of each step. (One (1) mark for naming the correct step, three (3) marks for detailing
each step and two (2) marks for the diagram.)
QUESTION 6:
[24 MARKS]
Explainthe order and the way in which DNA is packagedinto chromosomes and describe
the structure of a chromosome, supported by a labelled diagram. (Twenty (20) marks are
allocated for explaining and describing, and four (4) marks for the diagram.)
(24)
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END OF QUESTION PAPER.
Cell and Molecular Biology (CMB521S)
2024
1st Opportunity November
6