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BIO811S - BIOINFORMATICS - 1ST OPP- JUNE 2023 |
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nAmlBIA UnlVERSITY
OF SCIEnCE Ano TECHnOLOGY
FACULTY OF HEALTH, NATURAL RESOURCESAND APPLIED SCIENCES
SCHOOL OF NATURAL AND APPLIED SCIENCES
DEPARTMENT OF BIOLOGY, CHEMISTRY AND PHYSICS
QUALIFICATION : BACHELOR OF SCIENCE (HONOURS)
QUALIFICATION CODE: 08BOSC
LEVEL: 8
COURSE CODE: BIO8115
COURSE NAME: BIOINFORMATICS
SESSION: JUNE 2023
DURATION: 3 HOURS
PAPER: THEORY
MARKS: 120
EXAMINER(S)
FIRST OPPORTUNITY EXAMINATION QUESTION PAPER
Prof Percy Chimwamurombe
MODERATO-R: Dr Jean-Damascene Uzabakiriho
INSTRUCTIONS
1. Answer ALL the questions.
2. Write clearly and neatly.
3. Number the answers clearly.
PERMISSIBLE MATERIALS
Non-programmable Calculators
ATTACHMENTS
None
THIS QUESTION PAPER CONSISTS OF 2 PAGES (Including this front page)
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SECTIONA
1) Choose eukaryotic gene expression control example of your choice to describe
modelling whole genome circuits
(10 marks)
2) Compare and contrast different types of pairwise alignments of protein sequences.
(10 marks)
3) Regarding database searches, write short notes on:
a. E-values
(5 marks)
b. Similarity
(5 marks)
c. Homology
(5 marks)
4) Use the concept of gene copy number and how it can complicate single gene
circuits
(10 marks)
5) Use the example of a human disease complex to describe the concept of multigene
interactions.
(10 marks)
6) Describe a dynamic feedback control of gene expression.
(5 marks)
SectionB (EssaysSection)
1) Write a detailed essay on PSI-BLAST.
(30 marks)
2) Using examples, describe the use of a Biosafety Clearing House.(30 marks)
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