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CLC621S-CLINICAL CHEMISTRY 2B-JAN 2020 |
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NAMIBIA UNIVERSITY
OF SCIENCE AND TECHNOLOGY
FACULTY OF HEALTH AND APPLIED SCIENCES
DEPARTMENT OF HEALTH SCIENCES
QUALIFICATION: BACHELOR OF MEDICAL LABORATORY SCIENCES
QUALIFICATION CODE: O8BMLS
LEVEL: 6
COURSE CODE: CLC621S
COURSE NAME: CLINICAL CHEMISTRY 2B
SESSION:
JANUARY 2020
DURATION:
3 HOURS
PAPER:
MARKS:
THEORY
100
SUPPLEMENTARY / SECOND OPPORTUNITY EXAMINATION QUESTION PAPER
EXAMINER(S) | DR MUNYARADZI MUKESI
MODERATOR: | MR MAURICE NYAMBUYA
INSTRUCTIONS
1. Answer ALL the questions.
2. Write clearly and neatly.
3. Number the answers clearly.
PERMISSIBLE MATERIALS
1. NON PROGRAMMABLE CALCULATOR
THIS QUESTION PAPER CONSISTS OF FOUR PAGES (Including this front page)
Page 1 of4
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SECTION A [30]
QUESTION 1
[10]
1.0
State the principles of the following assays as used in clinical chemistry:
1.1
Electrophoresis
(2)
1.2
lon selective electrodes
(2)
1.3
The Biuret test
(2)
1.4 Osmometer
(2)
1.5
Estimation of Low Density Lipoprotein (LDL) using the Friedewald equation
(2)
QUESTION 2
[10]
2.0
A student performed an experiment on a urea samples and obtained the following results
presented in Table 1:
Table 1: Absorbance readings for urea measurements
Sample
Absorbance
Standard (10.0 mmol/L)
0.45
Control (Range: 10.0-15.0 mmol/L)
0.52
Patient sample (Ref Range: 2.5-8.3 mmol/L)
0.71
2.1
Calculate the urea concentration of the control and patient.
(4)
2.2
Comment on the results of both the control and patient.
(2)
2.3
Identify FOUR clinical uses of serum urea measurements.
(4)
Page 2 of4
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QUESTION 3
[10]
3.0
A patient presents with the following serum measurements:
Total protein
140 g/L
(RR: 65-85)
Albumin
29 g/L
(RR: 35-55)
a. Suggest TWO possible causes of such a presentation.
(2)
b. Propose further testing you would perform to help in making a diagnosis. Justify your
choice of test.
(2)
c. Illustrate the expected presentation of your analysis proposed in (b).
(6)
SECTION B [70]
QUESTION 4
[10]
4.0
A patient’s lipogram has the following results:
Total cholesterol
7.1 mmol/L
HDL cholesterol
1.1 mmol/L
Triglyceride
2.63 mmol/L
4.1
Calculate LDL using the Friedewald method (1 decimal place).
(2)
4.2
Describe the FOUR major classes of lipoproteins.
(8)
QUESTION 5
[10]
5.0
Discuss the significance of measuring serum and urine osmolality.
QUESTION 6
[15]
6.0
Discuss the collection and handling conditions of blood gas samples in the clinical
chemistry laboratory.
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QUESTION 7
[10]
7.0
Briefly describe the composition of total serum protein. Categorize the major protein
fractions and give examples of proteins in each of the different categories.
(10)
QUESTION 8
[10]
8.0
Give a brief description of how porphyrias develop. Use relevant examples to illustrate
your answer.
(10)
QUESTION 9
[15]
9.0
A patient presents at her Physician with general body malaise, spells of dizziness over a
long period and pronounced parlour. The Physician notices that the patient generally
looks unwell and collects blood samples for analysis by the Laboratory. He strongly feels
the patient has anaemia of chronic disease. Identify the tests which are likely to be
performed in the clinical chemistry laboratory. State the expected results which may
support the Physician’s provisional diagnosis. Justify the choice of your tests and
expected results. Only give relevant tests.
(15)
END OF EXAMINATION
TOTAL 100 MARKS
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