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CLC711S - CLINICAL CHEMISTRY 3 - 1ST OPP - JUNE 2022 |
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nAmlBIA unlVERSITY
OF SCIEnCE Ano TECHnOLOGY
FACULTYOF HEALTH,APPLIEDSCIENCESAND NATURALRESOURCES
DEPARTMENTOF HEALTHSCIENCES
QUALIFICATION:BACHELOR OF MEDICAL LABORATORY SCIENCES
QUALIFICATIONCODE: 08BMLS
LEVEL: 7
COURSECODE: CLC711S
COURSENAME: CLINICAL CHEMISTRY 3
SESSION:
JUNE 2022
DURATION: 3 HOURS
PAPER:
MARKS:
THEORY
120
FIRSTOPPORTUNITYQUESTION PAPER
EXAMINER(S) DR MUNYARADZI MUKESI
MODERATOR: PROF GREANIOUS A. MAVONDO
INSTRUCTIONS
1. Answer ALL the questions.
2. Write clearly and neatly.
3. Number the answers clearly.
THIS QUESTION PAPERCONSISTSOF THREEPAGES(Including this front page)
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QUESTION 1
SECTION A [60 marks]
[20 marks]
A 28-year-old man with a long history of intravenous drug abuse and chronic hepatitis B
presented with jaundice. Physical examination revealed an anaemic, malnourished man with
dependent pitting oedema and ascites. He has the following laboratory results:
Analyte
Result
Reference range
Total serum protein
Albumin
Calcium
Urea
Creatinine
Total bilirubin
Aspartate Aminotransferase (AST)
Alanine Aminotransferase (ALT)
Lactate Dehydrogenase (LOH)
Urinalysis
82
26
1.68
25.4
393
89
200
350
300
Positive for bilirubin
65-85 g/L
35-55 g/L
2.1-2.6 mmol/L
2.5-8.6 mmol/L
60-110 µmol/L
10-40 µmol/L
5-50 U/L
4-50 U/L
100-200 U/L
1.1 Discussthe clinical significance of the biochemical tests.
QUESTION 2
[20 marks]
An adult male patient presented at his physician complaining of episodes of stomach
cramps followed by diarrhoea usually in about 2 hours from consumption of dairy products.
The physician suspects lactose intolerance and would want to confirm the diagnosis. Discuss
the following:
2.1 Pathophysiology of the condition.
(10 marks)
2.2 Tests that will be useful in diagnosis
(10 marks)
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QUESTION 3
[20 marks]
An elderly patient was brought to the Casualty Department of a local hospital seemingly
unwell and looking frail. Family members reported that he had been in that state for almost
a week and was not getting better. However, it had started when he complained of severe
chest pain. The attending Physician requested the following biochemical tests: Myoglobin,
Total Creatine Kinase (CK), Creatine Kinase MB (CK-MB), Aspartate Transferase (AST),
Lactate Dehydrogenase (LDH), Troponin T and Troponin I.
3.1 Critically evaluate the usefulness of each test with respect to the case presentation. Use
relevant information to support your argument.
SECTION B [60 marks]
QUESTION 4
[20 marks]
Using the hypothalamus-anterior pituitary-thyroid axis, discuss direct dynamic, direct static,
and indirect assessment of anterior pituitary function.
QUESTION 5
[20 marks]
Discuss how macroscopic analysis of specimens aids in the diagnosis of disease in the clinical
chemistry laboratory. Use relevant examples to illustrate your answer.
QUESTION 6
[20 marks]
Briefly describe the importance of a Levey-Jennings chart as part of the process of ensuring
quality of the testing process in the laboratory.
TOTAL 120 MARKS
END OF EXAMINATION
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