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BIO801S - BIOINFORMATICS - 1ST OPP - JUNE 2022 |
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NAMIBIA UNIVERSITY
OF SCIENCE AND TECHNOLOGY
FACULTY OF HEALTH, APPLIED SCIENCES AND NATURAL RESOURCES
DEPARTMENT OF NATURAL AND APPLIED SCIENCES
QUALIFICATION : BACHELOR OF SCIENCE (HONOURS)
QUALIFICATION CODE: 08BOSC
LEVEL: 8
COURSE CODE: BI0811S
COURSE NAME: BIOINFORMATICS
SESSION: JUNE 2022
DURATION: 3 HOURS
PAPER: THEORY
MARKS: 120
FIRST OPPORTUNITY EXAMINATION QUESTION PAPER
EXAMINER(S) | Prof Percy Chimwamurombe
MODERATOR: | Pr Jean-Damascene Uzabakiriho
INSTRUCTIONS
1. Answer ALL the questions.
2. Write clearly and neatly.
3. Number the answers clearly.
PERMISSIBLE MATERIALS
Non-programmable Calculators
ATTACHMENTS
None
THIS QUESTION PAPER CONSISTS OF 2 PAGES (Including this front page)
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[60 marks]
1. Use the concept of gene copy number to explain (elaborate) how it can
complicate single gene circuits.
(10 marks)
2. Use the example of a human disease complex to describe the
concept of multigene interactions.
3. Choose eukaryotic gene expression control example of your
choice to describe modelling whole genome circuits
4. Compare and contrast different types of pairwise alignments
of protein sequences.
5. Describe a dynamic feedback control of gene expression.
6. Regarding database searches, write short notes on:
a. E-values
b. Similarity
c. Homology
(10 marks)
(10 marks)
(10 marks)
(5 marks)
(5 marks)
(5 marks)
(5 marks)
-Ee Section B(EssaysSection) =
,
7 [60 marks] «|
1. Describe the use of a Biosafety Clearing House using examples.
2. Write a detailed essay on PSI-BLAST.
(30 marks)
(30 marks)