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BPM821S - BIOSYNTHETIC PATHWAYS AND MOLECULAR BIOLOGY - 1ST OPP - NOV 2022 |
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nAm I BI A u n IVE RS ITV
OF SCIEnCE Ano TECHnOLOGY
FACULTYOF HEALTH,NATURAL RESOURCESAND APPLIEDSCIENCES
DEPARTMENT OF NATURALAND APPLIEDSCIENCES
QUALIFICATION: BACHELOROF SCIENCEHONOURS
QUALIFICATION CODE:08BOSC
LEVEL: 8
COURSENAME: BIOSYNTHETICPATHWAYS AND COURSECODE: BPM821S
MOLECULAR BIOLOGY
SESSION:NOVEMBER 2022
DURATION: 3 HOURS
PAPER:THEORY
MARKS: 100
EXAMINER
FIRSTOPPORTUNITY QUESTION PAPER
DR LAMECH MWAPAGHA
MODERATOR: DR EMMANUEL NEPOLO
INSTRUCTIONS
1. Answer ALL the questions.
2. Write clearly and neatly.
3. Number the answers clearly.
4. All written work MUST be done in BLUEor BLACKink.
PERMISSIBLEMATERIALS
None
THIS QUESTION PAPERCONSISTSOF FIVE (5) PAGES
(Including this front page)
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QUESTION 3
[10]
The signalling pathway below is responsible for controlling processes such as inflammation,
cell proliferation and apoptosis.
TNFR
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a) Name the signalling pathway
(1)
b) Briefly describe the activation of the signalling pathway
(5)
c) Outline FOUR (4) functions of the canonical Wnt signalling pathway
(4)
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QUESTION 6
[18]
a) State FOUR (4) reasons why cancer staging is important?
(4)
b) Outline SEVEN (7) reasons why cancer biomarkers are missing the mark in cancer prognosis
and diagnosis
(7)
c) Highlight some of the Clinical applications and uses of Cancer Biomarkers
(7)
QUESTION 7
[14]
a) Why is the activation of telomerase activity a "neoplastic" trait?
(4)
b) Briefly discuss the following hallmarks of cancer;
(10)
I. Deregulating cellular energetics;
II. Evading growth suppressors;
Ill. Activating invasion and metastasis;
IV. Resisting cell death;
V. Genomic instability and mutation;
THE END
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